UltraMem™ Nuggets TFF Cassettes

Membrane Solutions can provide tangential filtration solutions, the UltraMem Nuggets TFF cassettes, for our customers, to fulfill the needs in bio-pharmaceutical applications. UltraMem Nuggets cassettes are composed of UltraMem high performance UF membranes. It is a high performance tangential flow filter product with safety, convenience and cost efficiency for bio-pharm and bio-tech process.Typical applications of UltraMem Nugget cassettes include but no limited to the concentration and separation of monoclonal antibiotics, recombinant protein drugs, virus-vectors, vaccines, plasmid, mRNA LNP, particulate dispersions, cell culture clarications, buffer exchange, etc.
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Features

  • Fast and reliable linear amplication from the lab to production scale
  • Robust and reliable design enables UltraMem Nuggets to withstand high pressure and temperature (max 5bar@40℃)
  • Easy to operate, fast installation and cleaning, ensure reliable yield; <10% ux decline after 200 hrs caustic wash; Max 210g/L concentration can be achieved
  • Broad chemical compatibility
  • Multiple MWCOs and/or pore size to choose, combined with multiple process area, and membrane materials, meet your demands

Applications

  • Concentration of biomolecules (recombinant proteins, monoclonal antibodies, viruses, etc.)
  • Dialysis, desalination, and buffer replacement
  • Separation and purification
  • Remove endotoxins
  • Except for macromolecules, etc

Technical Parameters

 

Membrane Type Modifed PES Regenerated Cellulose
Filtration Type UF MF UF
MWCO 5/8/10/30/50/70/100/300/500 kD 0.1/0.2/0.45 μm 1/2/3/10/30/100/300 kD
Flow Rate Fast Medium
Static Protein Adsorption Low Very Low
pH Range 1-14 2-13
Recommendations Fast process of protein solutions;       
harsh process and cleaning conditions		 Viscous and high
conc.%liquid,where high recovery is demanded
Materials of Construction Housing Silicone (Soft) Resin(Rigid)
Membrane Modifed PES with nonwoven support Regenerated Cellulose with nonwoven support
Channel/Fleece Polypropylene Polypropylene
Preservation Liquid 20%glycerol+0.05 M NaOH 20%glycerol+0.05 M NaOH
Operating Housing Silicone (Soft) Resin(Rigid)
Maximum Inlet Pressure 5.5bar@25℃;4 bar@40℃ 5.5 bar@25℃;5 bar@40℃
Operating pH Range 1-14 for PES membrane,2-13 for RC membrane
Dimensions Filtration Area Silicone (Soft)         Resin(Rigid) Processing Volumes
100 cm² L/W/H:205×56×2 L/W/H:205×56×4 100-1000 ml
0.1 m² L/W/H:205×56×16 L/W/H:205×56×16 0.2-10L
0.5 m² L/W/H:205×173×17 L/W/H:205×178×16 >2L
2.5 m² L/W/H:205×173×88 L/W/H:205×178×72 >10L

 

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