Hollow Fiber Filters

CleaSep hollow fiber filters are currently available in 17 different dimensions, suitable for R&D, pilot testing and commercial production. The filters demonstrate stable performance with reliable linear scalability when maintaining identical length but varying surface areas. Their material composition exhibits excellent chemical compatibility with various cleaning agents, ensuring safe and effective cleaning and disinfection of the filtration system. Compared to traditional PES, the modified PES membrane not only delivers higher flow rates, greater filtration capacities, shorter processing times and improved yields, but also features low protein-binding, low-blockage and easy-clean characteristics. The modification technology optimizes PES rigidity while enhancing membrane flexibility, enabling tolerance to higher process disturbances and shear rates.
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Specs Product Parameters Availability Price

 

Related Documents

 

CleaSep Hollow Fiber Filters-Datasheet

 CleaSep Hollow Fiber Filters-Quick Usage Guide CleaSep Hollow Fiber Filters-Technical Manual  

Features

  • Fast and reliable lab-to-production linear scalability
  • Modified PES material, lower protein binding and blockage, higher flow rate and filtration capacit
  • Simple and reliable product design, no need for additional assembly and fixtures, easy to install and clean
  • Narrow pore size distribution, high porosity, and high product recovery rate
  • Good chemical compatibility and temperature resistance, can be cleaned and regenerated with a 1N sodium hydroxide aqueous solution at up to 80 ℃, and can withstand SIP sterilization

Applications

UF

  • Purification and concentration of recombinant proteins/antibodies
  • Purification, concentration, and dialysis of vaccines
  • Concentration of virus, virus-like particles, virus vector
  • Fractionation and concentration of nano materials and latex particles
  • Rinsing, liquid exchange, and concentration of liposome

  • Separation of natural products

MF

  • Recovery and washing of cells and bacterial cells
  • Clarification of fermentation broth and cell lysis buffer

 

Technical Parameters

Parts Material

Hollow Fiber

Modified Polyether Sulfone

Potting

Epoxy

Filter Housing

Polysulfone

Sealing Ring

Silicone

Coupling

Nylon+Fiber Glass(PI,PR)or Silicone(MN,LA)

Port Plug

Polypropylene(PI,PR)or Silicone(MN,LA)

Protective Solution

30wt%Glycerin+0.4wt%NaOH Solution

  Operating
Specifications

Maximum Feed Pressure

36psi/2.5bar@20℃

Maximum TMP

Ultrafiltration 30psi/2.1bar@20℃
Microfiltration 20psi/1.4bar@20℃

Operating Temperature

≤40℃(Can Withstand SIP Sterilization)

Operating pH Range

1-14

Regulatory
Information

Biosafety

Meets USP<87>and FDA 21CFR Testing

Dissolved Matter

Meet the Requirements of ISO 10993-5(Cytotoxicity)

Quality System

Production under ISO9001 and GMP Quality Requirements

Integrity

100% Flux and Integrity Testing
Parameters of CleaSep Hollow Fiber Filters
Type Length
(mm)		 Processing
Capacity(L)		 Filtration
Rating		 Number of Fibers Area(m²)
0.5mm* 1.0mm* 1.5mm* 0.5mm* 1.0mm* 1.5mm*
miniLab 320  0.3  10 kDa 6  3  2  0.003  0.003  0.003 
640  0.6  30 kDa 6  3  2  0.006  0.006  0.006 
miniLab+ 320  0.7  50 kDa 12  4  4  0.006  0.006  0.006 
640  1  100 kDa 12  4  4  0.012  0.012  0.012 
Lab 320  1  300 kDa 36  18  10  0.018  0.018  0.015 
640  2  500 kDa 36  18  10  0.036  0.036  0.030 
Lab+ 320  5  750 kDa 150  75  28  0.075  0.075  0.042 
640  10  0.22μm 150  75  28  0.150  0.150  0.084 
Pilot 320  15  0.45μm 336  168  67  0.160  0.160  0.100 
640  30  0.65μm 336  168  67  0.330  0.330  0.200 
1150  50    336  168  67  0.600  0.600  0.360 
Pilot+ 320  15    476  238  122  0.230  0.230  0.180 
640  30    476  238  122  0.470  0.470  0.360 
1150  50    476  238  122  0.850  0.850  0.660 
Process 320  120    3600  1700  700  1.800  1.700  1.050 
640  250    3600  1700  700  3.610  3.400  2.110 
1150  500    3600  1700  700  6.500  6.130  3.790 

  *Fiber ID of Hollow Fiber Filters

FAQ

1.What are the application cases for the hollow fiber filters produced by Membrane Solutions?

The CleaSep hollow fiber filters have been successfully applied in:

  • Exosome concentration
  • Antibody concentration
  • Liposome concentration
  • Nanoparticle collection
  • Clarification of various E. coli lysates and yeast fermentation broths
  • Cell perfusion culture
  • Beer crossflow filtration
  • Wine clarification filtration
  • Tea beverage clarification filtration, among others

2.What application cases are currently available?

The main application cases are in biopharmaceuticals—including exosomes, antibodies, mycoplasma, viral particles, liposomes, collagen, and fermentation cells—as well as in the beer industry.

3.What are the application cases of MS hollow fiber filters in ex4.osome concentration, and how effective are they?

The MS hollow fiber filters have successful applications in exosome concentration. For different exosome systems, we generally recommend removal ratings of 100–500 kD.

4.What are the main differences between hollow fiber modules and membrane cassettes in terms of applications and product performance? Which one is currently more widely used in the market?

Both are typical products for tangential flow filtration in biopharmaceuticals. Membrane cassettes have a longer history, are more mature, and have more well-developed process designs.

Hollow fiber modules are newer and offer unique advantages in certain applications:
For shear-sensitive feed solutions, hollow fibers provide better control with minimal shear, making them preferable to cassettes.
For large-volume liquid processing (e.g., clarification filtration), hollow fiber modules also have an advantage over cassettes.

5.What are the materials and features of hollow fiber membranes?

They are made of modified polyethersulfone (mPES), featuring low adsorption and easy cleaning, and represent the mainstream material on the market.
In the future, there are plans to develop versions made of polysulfone (PSU) and polyvinylidene fluoride (PVDF).

6.What removal ratings are available for the hollow fiber filters produced by Membrane Solutions?

The CleaSep hollow fiber filters are available in:
Microfiltration series: 0.22 / 0.45 / 0.65 μm
Ultrafiltration series: 10 / 30 / 50 / 100 / 300 / 500 / 750 / 1000 kD

7.What filtration areas are available for the hollow fiber filters produced by Membrane Solutions?

The CleaSep hollow fiber filters cover a wide range of specifications for laboratory, pilot, and large-scale applications, with membrane areas ranging from 30 cm² to 6.5 m². Customized products with different effective lengths and filtration areas can also be developed upon customer request.

8.How should one choose the removal rating for a hollow fiber membrane?

Selection is based on the target molecule:
For permeation mode, the membrane pore size should be at least 5–10 times larger than the target molecule.
For retention mode, the membrane pore size should be about 1/3–1/5 of the target molecular weight.

9.What are the features / key selling points of the hollow fiber filters produced by Membrane Solutions?

The CleaSep hollow fiber filters feature:

  • High flux, delivering greater filtration efficiency
  • Uniform pore size distribution, ensuring higher retention rates and recovery
  • Comprehensive product range, covering wide removal ratings and diverse filtration areas
  • Excellent cost-effectiveness

10.Are the hollow fiber membranes resistant to NaOH, and if so, what concentrations can they tolerate?

They have good chemical compatibility and can withstand higher temperatures, pressures, and cleaning concentrations, including up to 1 N NaOH.

11.What is the operating pH range of the hollow fiber membranes?

The hollow fiber membranes can tolerate a pH range of 1–14.

12.What is the pressure resistance of the hollow fiber filters?

Ultrafiltration: Maximum feed pressure 36 psi / 2.5 bar @ 20°C, maximum transmembrane pressure 30 psi / 2.1 bar @ 20°C
Microfiltration: Maximum feed pressure 36 psi / 2.5 bar @ 20°C, maximum transmembrane pressure 20 psi / 1.4 bar @ 20°C

13.Can our hollow fiber filters be steam sterilized?

They can be Steam-in-Place (SIP), with a one-time quality guarantee. When ordering, add the suffix -HT to the product code. The typical Steam-in-Place (SIP) conditions are 121°C for about 20 minutes.

14.What factory standards do the hollow fiber filters produced by Membrane Solutions comply with?

The CleaSep hollow fiber filters comply with USP87 biocompatibility testing and FDA21CFR food-grade certification. Each product undergoes water flux and integrity testing before leaving the factory.

15.Is the spinning process used by Membrane Solutions (MS) independently developed?Does the fiber structure of MS membranes meet international standards?

The CleaSep hollow fiber filters by MS are entirely independently developed, from fiber development to module design. Compared with leading international competitors, the overall performance of MS biopharmaceutical filtration products reaches about 90% of the top-level brands, with certain performance aspects (e.g., filtration efficiency) even surpassing the leading brands.

16.How are the hollow fiber filters produced by Membrane Solutions used?

After purchasing the CleaSep hollow fiber filters, we provide instructional videos and product manuals to guide customers through all procedures, including rinsing, filtration, cleaning, and storage.

17.What are the advantages of MS hollow fiber filters?

The CleaSep hollow fiber filters can replace 90% models of mainstream brands.
In biopharmaceutical applications, compared with mainstream competitors, MS hollow fiber filters offer comparable performance, high production capacity (over 150,000 m² of fiber per year), and fast delivery. Competitive pricing is also a fundamental advantage.

18.Besides the 1.4-meter fibers, can MS provide hollow fibers in other lengths?

After recent equipment upgrades, we can provide hollow fibers up to 2.2 meters in length, with custom adjustments available according to customer requirements.

19.Hollow fiber membranes are available in various membrane areas for testing and use.

They are available in over 17 different sizes, suitable for R&D, laboratory-scale, pilot-scale, and commercial production.