Hollow Fiber Filters

Introduction

CleaSep provides 17+ different dimensions for hollowfiber filters, which can be used for R&D test, pilot application and commercial production. The hollow fiber filters adopt automatic production process, which ensures the consistency of its performance and the simple and reliable scalability from laboratory to production. The material composition of the hollow fiber filter has excellent chemical compatibility and can tolerate a variety of chemical cleaning agents to ensure safe and effective cleaning and disinfection of the filtration system. Compared with traditional PES, CleaSep hollow fiber is made of modified PES, which not only provides higher flow rate, higher filtration load, shorter process time and higher yield, but also has the lower protein adsorption, low blockage and easier cleaning. The modification technology optimizes the rigidity of PES, improves the flexibility of membrane material, and can withstand higher process disturbance and shear rate.

Product Features

• Scalability from laboratory to production
• Modified PES fiber provides lower protein adsorption, high flux rates, low protein binding and high yield
• Highly asymmetric structure, narrow pore size distribution and high recovery rete
• Reliable and simply design, easy to install and clean without additional asssembly and fixture
• Better chemical compatibility can withstand higher temperature, pressure and cleaning concentration (1 NaOH)

Applications

• Purification and concentration of recombinant protein or antibody

• Purification, concentration and dialysis of vaccine

• Concentration of viruses, virus-like particles and virus vectors

• Fractionation & concentration of nano materials and latex particles

• Recovery & washing of cells and bacteria

• Clarify fermentation broth and cell lysate, collect and clean treated particles or beads

Product Information

Material

Parts	Material
Hollow Fiber	Modified Polyethersulfone
Potting	Epoxy
Filter Housing	Polysulfone
Sealing ring	Silicone
Coupling	Polycarbonate(PI,PR) or Silicone(MN,LA)
Port Plug	Polypropylene(PI,PR) or Silicone(MN,LA)
Protective solution	20wt% glycerin+0.2wt% NaOH solution

Operating Specifications

Ultrafiltration

Maximum feed pressure	36psi/2.5bar@20℃
Maximum TMP	30psi/2.1bar@20℃
Operating temperature	≤40℃
Operating pH range	1-14

Microfiltration

Maximum feed pressure	36psi/2.5bar@20℃
Maximum TMP	20psi/1.4bar@20℃
Operating temperature	≤40℃
Operating pH range	1-14

Regulatory information

Biosafety	Meets USP<87>and FDA 21CFR testing
Dissolved matter	Meet the requirements of ISO 10993-5(cytotoxicity)
Quality system	Production under ISO9001 and GMP quality requirements
integrity	100% flux and integrity testing

Dimensional Drawing

Ordering Information

Hollow Fiber	Membrane Material	Application	Removal Rating	Membrane Inner Diameter	Effective Length
HF	E PES	MN mini Lab	010  10kD	05  0.5mm	0320  320mm
		MP miniLab+	030  30kD	10  1.0mm	0640  640mm
		LA  Lab	050  50kD		1150  1150mm
		LP  Lab+	100  100kD
		PI  Pilot	300  300kD
		PP  Pilot+	500  500kD
		PR  Process	750  750kD
			022  0.22μm
			045  0.45μm
			065  0.65μm
Membrane type	Membrane material	Application	Filtration Rating	Fiber ID	Length

HFELA022100320, means a PES hollow fiber filter have a pore size of 0.22μm, fiber inner diameter is 1.0mm, effective length is 320mm, suitable for laboratory use.